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目的观察抗氧化治疗(普罗布考)对急性期脑梗死的临床疗效及其对血清炎性因子的影响,探讨普罗布考在脑梗死防治中的价值。方法选择急性期脑梗死患者60例,随机分成二组:治疗组(30例)在常规药物治疗的基础上加用普罗布考0.5g,2次/d;对照组(30例)常规药物治疗,不用任何其他降血脂药物和影响脂代谢的药物,均治疗4周。分别在治疗前后测定血清炎性因子及血脂水平并进行NIHSS评分。结果治疗4周后,治疗组血清炎性因子水平较对照组明显降低(P<0.05),而NIHSS评分,治疗组改善明显优于治疗前及对照组(P<0.05)。结论普罗布考有很强的抗氧化作用及调脂作用,和阿司匹林、辛伐他汀联用,能减少神经元的损伤,提高急性脑梗死患者的近期疗效。
Objective To observe the clinical effect of anti-oxidative therapy (probucol) on acute cerebral infarction and its effect on serum inflammatory factors, and to explore the value of probucol in the prevention and treatment of cerebral infarction. Methods Sixty patients with acute cerebral infarction were randomly divided into two groups: the treatment group (30 cases) was given probucol 0.5g twice daily on the basis of conventional drug therapy; the control group (30 cases) routine drug treatment , Without any other hypolipidemic drugs and drugs that affect lipid metabolism, were treated for 4 weeks. Serum levels of inflammatory cytokines and lipids were measured before and after treatment and NIHSS scores. Results After 4 weeks of treatment, the level of serum inflammatory cytokines in the treatment group was significantly lower than that in the control group (P <0.05), while the NIHSS score in the treatment group was significantly better than that before treatment and in the control group (P <0.05). Conclusion Probucol has a strong anti-oxidation and lipid-lowering effects, combined with aspirin and simvastatin can reduce neuronal damage and improve the short-term efficacy of patients with acute cerebral infarction.