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目的分析吉林省新生儿先天性甲状腺功能减低症(CH)的筛查情况,探讨新生儿疾病筛查在出生缺陷干预中的重要作用。方法新生儿出生72 h后,并充分哺乳,采集足跟血滴于专用滤纸上,测定血片中促甲状腺激素(TSH)的浓度。确诊使用化学发光法检测患儿血清中的游离T3(FT3)、游离T4(FT4)以及TSH。结果 2007年4月～2012年12月,共筛查新生儿634 290例,筛查率为81.85%,筛查率呈逐年上升趋势。检出先天性甲状腺功能减低症患儿175例,发病率为1/3625。结论吉林省新生儿先天性甲状腺功能低下症的发病率与北方其他城市相近,低于全国平均水平。新生儿疾病筛查是防止智力低下,提高出生人口素质的一项重要措施。
Objective To analyze the screening of congenital hypothyroidism (CH) in neonates in Jilin Province and to explore the important role of neonatal screening in the intervention of birth defects. Methods After neonatal birth 72h, and fully breast-feeding, heel blood was collected on a special filter paper to measure the thyroid-stimulating hormone (TSH) concentration in blood films. The serum levels of free T3 (FT3), free T4 (FT4) and TSH in children were detected by chemiluminescence. Results From April 2007 to December 2012, 634 290 neonates were screened, the screening rate was 81.85%, the screening rate showed an upward trend year by year. 175 cases of congenital hypothyroidism were detected in children, the incidence rate of 1/3625. Conclusions The incidence of congenital hypothyroidism in newborns in Jilin Province is similar to other cities in the north, lower than the national average. Neonatal screening is to prevent mental retardation and improve the quality of the birth of an important measure.