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通过对细菌脂多糖(LPS)核心糖脂(CGL)抗体和类脂A抗体有关方面如两者的交叉保护作用、作用机理、血清浓度与细菌感染的关系、对内毒素的中和作用、抗体的使用时间以及抗体类型的作用等的充分阐述,旨在寻找用LPS共同抗原的高免疫血清和单克隆抗体对革兰氏阴性菌败血症和休克进行免疫预防和免疫治疗。此外,作者还对实验结果差异的可能原因进行了分析。
Through the cross-protection of bacterial lipopolysaccharide (LPS) core glycolipid (CGL) antibodies and lipid A antibodies, the mechanism of action, the relationship between serum concentration and bacterial infection, endotoxin neutralization, antibody The duration of use, and the role of antibody types, etc., and aims to find immunosuppressive and immunotherapy for Gram-negative septicemia and shock using highly immune serum and monoclonal antibodies against LPS common antigens. In addition, the author also analyzed the possible causes of differences in experimental results.