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作者采用测定红细胞内~(203)Hg结合量的方法,比较氯化甲基汞(CH_3HgCl)和无机氯化汞对人红细胞膜的通透力。结果发现不论在37℃或0℃时,三分钟内甲基汞在红细胞内的最大结合力可达80～90%。甲基汞浓度为10~(-8)、10~(-6)和10~(-4)M时,与红细胞的结合力相同,但氯化汞在10~(-6)和10~(-8)M时,结合力减低。半胱氨酸可抑制甲基汞和氯化汞与红细胞的结合力,但二巯基赤藓醇(DTT,Dithiothreitol)的这种作用不强。血浆蛋白对甲基汞结合力稍有抑制作用,而对氯
The authors used a method of determining the amount of ~ (203) Hg bound in erythrocytes and compared the permeation of methylmercury chloride (CH_3HgCl) and inorganic mercuric chloride on human erythrocyte membrane. The results showed that the maximum binding capacity of methylmercury in erythrocytes up to 80 ~ 90% within three minutes at 37 ℃ or 0 ℃. The binding capacity of erythrocytes was the same at 10 ~ (-8), 10 ~ (-6) and 10 ~ (-4) M of methylmercury, but at 10 ~ (-6) and 10 ~ -8) M, the binding force decreases. Cysteine inhibits the binding of methylmercury and mercuric chloride to erythrocytes, but this effect of dithiothreitol (DTT) is not strong. Plasma proteins have a slight inhibitory effect on methylmercury binding, while on chloride