本文报道了河南省洛阳、鹤壁两地区２２万人群中有关唇裂和（或）腭裂调查及遗传学研究结果。先证者一级亲属患病率２０．６６‰，二级亲属３．１７‰，分别是群体患病率（０．４５‰）的４４倍和７倍。唇裂和（或）腭裂遗传度：一级亲属７１．８９％±７．３３％，二级亲属６６．４２％±２１．２３％，加权平均遗传度７１．３１％±６．９３％，说明遗传因素在其发病中起重要作用。 This paper reports about the investigation of cleft lip and / or cleft palate and genetic studies in 220,000 Chinese people in Luoyang and Hebi of Henan Province. The prevalence of first-degree relatives of probands was 20.66 ‰, while that of second-degree relatives was 3.17 ‰, which were respectively 44 times and 7 times of the prevalence rates of the population (0.45 ‰). Cleft lip and / or palate heritability: 71.89% ± 7.33% of first-degree relatives, 66.42% ± 21.23% of second-degree relatives, and 71.31% ± 6.93% of weighted average heritability, indicating Genetic factors play an important role in its pathogenesis.