ＢＣＲ ＡＢＬ是一种酪氨酸激酶活化物 ,存在于几乎所有的慢性粒细胞白血病 (ＣＭＬ)患者体内。研究表明 ,仅ＢＣＲ ＡＢＬ一种因素即可导致ＣＭＬ。而ＳＴＩ 571是一种特异性酪氨酸激酶抑制剂 ,通过竞争结合酶的ＡＴＰ结合部位而抑制蛋白质的酪氨酸磷酸化过程 ,它能导致表达Ｂ BCR ABL is a tyrosine kinase activator found in almost all patients with chronic myeloid leukemia (CML). Studies show that only one factor of BCR ABL can lead to CML. While STI 571 is a specific tyrosine kinase inhibitor that inhibits the tyrosine phosphorylation of proteins by competing with the ATP-binding site of the enzyme, which leads to the expression of B