长期服用抗精神病药的患者常常发生体重增加或肥胖。这对躯体、精神和社会活动都带来不良影响。但其确切机制迄今未明,有关的研究报道不多。 一、影响体重增加的因素 (1)服药时间:一般认为服药头几个月体重增加最快,约0.75kg/周,以后增加较慢。长坂(1964)认为高度肥胖的发生率随服药时间的延长而增高。持续服药者便持续肥胖,中断用药则体重迅速减少。(2)服药剂量与体重增加无一定联 Long-term use of antipsychotic patients often occur weight gain or obesity. This has adverse physical, mental and social activities. However, the exact mechanism has not been known so far, and few reports have been reported. First, the factors that affect weight gain (1) taking time: generally considered the first months of taking the first weight gain the fastest, about 0.75kg / week, later increased slower. Nagasaka (1964) that the incidence of obesity increased with the extension of time. Persistent medication will continue to obesity, discontinued medication is rapidly reduced body weight. (2) medication dose and weight gain without a certain combination