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星形胶质细胞在中枢神经系统中扮演重要角色。此外,作为分泌性细胞,星形胶质细胞还活跃地参与被膜囊泡介导的细胞间通讯。当囊泡膜与细胞质膜融合时,储存在这些囊泡中的胶质细胞信号分子流出细胞外。这个过程称之为胞吐作用,受SNARE蛋白调节,为细胞内钙水平升高所引起。钙来源于细胞内的内质网储存,它从细胞外的进入归因于星形胶质细胞的细胞钙动力学。本文探讨星形胶质细胞胞吐作用中的钙管理,以及储存胶质细胞信号分子的膜囊泡特性,包括囊泡融合和囊泡内容物流出的机械动力学。在星形胶质细胞中,细胞内钙水平增加和囊泡腔中分泌物流出的延迟略长于神经元。这种相对松散的兴奋-分泌耦合可能根据星形胶质细胞在神经网络调控中的参与来调整。
Astrocytes play an important role in the central nervous system. In addition, as a secreted cell, astrocytes are also actively involved in envelope-mediated cell-cell communication. Glial cell signaling molecules stored in these vesicles flow out of the cell when the vesicles fuse with the plasma membrane. This process is called exocytosis and is regulated by the SNARE protein, which is caused by elevated intracellular calcium levels. Calcium is derived from intracellular storage of endoplasmic reticulum and its extracellular entry is due to cellular calcium dynamics of astrocytes. This article explores the calcium management of astrocyte exocytosis and the membrane vesicle properties of glial cell signaling molecules, including the vesicle fusion and the mechanical kinetics of vesicle efflux. In astrocytes, increased intracellular calcium levels and delayed efflux of secretions from the vesicle compartment are slightly longer than neurons. This relatively loose excitement - secretion coupling may be adjusted according to the involvement of astrocytes in neural network regulation.