论文部分内容阅读
转化生长因子-β(transforming growth factor-β,TGF-β)作用复杂,广泛参与哺乳动物的各种病理生理过程如影响细胞的增殖分化、参与心力衰竭发展。TGF-β信号通路关键的信号传导分子为胞浆蛋白Smads。TGF-β诱导分化心肌成纤维细胞,刺激胶原蛋白等细胞间质成分的合成,促进细胞间质的沉积和抑制弹性蛋白酶等的分泌,刺激蛋白酶抑制剂的表达,从而抑制Ⅰ型胶原成分的降解,促进心肌纤维化发展,进一步了解TGF-β/Smads通路转导蛋白的作用及机制,通过抑制TGF-β/Smads通路转导蛋白作为治疗新靶点为最终防止心力衰竭提供了新的思路。
The role of transforming growth factor-β (TGF-β) is complex and extensively involved in various pathophysiological processes in mammals, such as affecting the proliferation and differentiation of cells and participating in the development of heart failure. The key signal transduction molecule of TGF-β signaling pathway is cytoplasmic Smads. TGF-β induces the differentiation of cardiac fibroblasts, stimulates the synthesis of collagen and other interstitial components, promotes the deposition of interstitial cells and inhibits the secretion of elastase, stimulates the expression of protease inhibitors and thus inhibits the degradation of type I collagen components , Promote the development of myocardial fibrosis, and further understand the function and mechanism of TGF-β / Smads pathway transduction protein, and provide a new idea for finally preventing heart failure by inhibiting the TGF-β / Smads pathway transducin as a new therapeutic target.