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目的 探讨载脂蛋白 (a)基因C93T和G12 1A多态性与缺血性脑血管病的关系。方法 应用病例对照研究 ,在 12 4 9例缺血性脑血管病和 12 4 9例非脑血管病人群中采用PCR和分子杂交技术检测基因型 ,将病例组和对照组各基因型和等位基因频率进行 χ2 检验。结果 载脂蛋白 (a)基因C93T和G12 1A多态性基因型及等位基因频率在缺血性脑血管病组和对照组中无明显区别 ,也与脑梗死家族史无关。多因素Logistic回归分析表明 93C和 12 1A等位基因携带者均不增加缺血性脑血管病的危险。结论 Apo(a)基因C93T和G12 1A多态性与中国人缺血性脑血管病的关系不明显。
Objective To investigate the relationship between apolipoprotein (a) gene C93T and G12 1A polymorphisms and ischemic cerebrovascular disease. Methods Using case-control study, genotypes were detected by PCR and molecular hybridization in 124.9 ischemic cerebrovascular diseases and 124.9 non-cerebrovascular patients. The genotypes and alleles of cases and controls Gene frequency χ2 test. Results The polymorphisms of C93T and G12 1A of apolipoprotein (a) gene and allele frequencies were not significantly different between ischemic cerebrovascular disease group and control group, and also had no relationship with family history of cerebral infarction. Multivariate Logistic regression analysis showed that 93C and 12 1A allele carriers did not increase the risk of ischemic cerebrovascular disease. Conclusion There is no obvious relationship between Apo (a) gene C93T and G12 1A polymorphisms and Chinese ischemic cerebrovascular disease.