【摘 要】
：
N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺是最近从海洋细菌中分离得到的一种新型的天然杀藻剂,以D-丙氨酸为原料合成了该化合物,并用类似的方法首次合成了它的类似物2,3和
【机 构】
：
南开大学元素有机化学研究所元素有机化学国家重点实验室,
论文部分内容阅读
N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺是最近从海洋细菌中分离得到的一种新型的天然杀藻剂,以D-丙氨酸为原料合成了该化合物,并用类似的方法首次合成了它的类似物2,3和4.其关键步骤为通过将取代的4-噻唑甲酸制成混酐与色胺连接的偶联反应.各中间体都通过1HNMR和13CNMR得到证实.最终产品通过1HNMR,13CNMR和HRMS证实,与文献所报道相一致.
N- (2- (1H-indol-3) ethyl] -2-acetylthiazole-4-carboxamide is a new type of natural algicide recently isolated from marine bacteria, D-alanine This compound was synthesized as a starting material and its analogues 2, 3 and 4 were synthesized for the first time in a similar manner The key step was the coupling reaction by the attachment of the substituted 4-thiazolecarboxylic acid to the tryptamine. The intermediates were confirmed by 1 HNMR and 13CNMR.The final product was confirmed by 1HNMR, 13CNMR and HRMS, which was consistent with that reported in the literature.
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