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Land use and land cover change(LULCC) strongly influence regional and global climate by combining both biochemical and biophysical processes. However, the biophysical process was often ignored, which may offset the biogeochemical effects, so measures to address climate change could not reach the target. Thus, the biophysical influence of LULCC is critical for understanding observed climate changes in the past and potential scenarios in the future. Therefore, it is necessary to identify the mechanisms and effects of large-scale LULCC on climate change through changing the underlying surface, and thus the energy balance. The key scientific issues on understanding the impacts of human activities on global climate that must be addressed including:(1) what are the basic scientific facts of spatial and temporal variations of LULCC in China and comparative countries?(2) How to understand the coupling driving mechanisms of human activities and climate change on the LULCC and then to forecasting the future scenarios?(3) What are the scientific mechanisms of LULCC impacts on biophysical processes of land surface, and then the climate?(4) How to estimate the contributions of LULCC to climate change by affecting biophysical processes of land surface? By international comparison, the impacts of LULCC on climate change at the local, regional and global scales were revealed and evaluated. It can provide theoretical basis for the global change, and have great significance to mitigate and adapt to global climate changes.