目的：观察束缚挤压造成复合挤压伤大鼠受压过程中的心电图改变及生存率变化规律。方法雄性健康SD大鼠80只，随机分为束缚挤压模型组（40只）和单纯饥饿对照组（40只）。模型组大鼠四肢束缚固定同时给予双下肢3.5 kg重物挤压72 h造模，在整个挤压过程中及解压后24 h持续监测心电图，分析不同时间点心率、ST段偏移量、T波高度及心电图动态变化规律；同时在解压后继续观察7 d，对生存率进行统计。对照组给予禁食水72 h处理，同样进行心电图监测及生存率统计。结果束缚挤压模型大鼠出现不同程度的心率减慢、ST段升高及T波高尖改变。随挤压时间延长，心率呈持续减低趋势，挤压24 h后变化明显；挤压早期即可出现ST段抬高，24~48 h进入平台期，48~72 h升高明显；T波在挤压48 h后T波高尖明显；复合束缚挤压伤大鼠死亡率高，挤压72 h生存率仅为55%，解压后7 d降至25%，其中挤压48~72 h之间及解压后24 h为死亡高发期。单纯饥饿对照组大鼠心电图改变不明显，生存率为100%。结论复合束缚挤压伤心电图变化呈现多样性，大体可分为3种类型，其早期异常改变与不良预后相关。“,”Objective To investigate the effects of combined restrain stress and crush injury on electrocardiographic changes and survival rate. Methods Eighty male adult sprague dawley rats were separated randomly into two groups, each group had forty rats, one was for retrain stress and crush injury(model group), the other was for hunger and thirst (control group). The rats of model group were fixed on the operation boards with their bilateral hind limbs compressed by 3.5 kg weight for 72 h, so as to simulate the situation in earthquake. Electrocardiography were performed during the whole perioid of compression and 24 h after decompression. After decompression the rats were fed in normal condition for 7 day to observe the survival rate. The rats of control group were deprived of food and water for 72 h, electrocardiography and survival rate were also collected. Results Different degrees of slow heart rate, elevated ST segment, and tall-peaked T wave were observed in most rats in model group. With the extension of compression time the heart rate continued to slow down , and dropped significantly after 24 hours. ST segment elevation appeared in the early period of compression and the shape of ST segment stayed at the same level during the period of 24~48 h after decompresion but was elevated significantly during the period of 48~72 h after decompression. High and sharp T waves showed up 48h after compression. No significant electrocardiographic changes were observed in control group. Most rats died during the period of combined compression, the whole survival rate before decompression was only 55%. The survival rate dropped the fastest during the period of 48 to 72 hours of compression and 24 hours after decompression, and reached 25% 7 days after decompression. The survival rate of control group rats was 100%. Conclusion Crush injury combined restrain stress causes myocardial ischemia very early, thus leading to poor prognosis.