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目的研究临床确有疗效的外用制剂皮粘散治疗慢性皮肤溃疡的作用及其机制。方法通过外伤复合冰醋酸复制慢性皮肤溃疡大鼠模型,观察皮粘散对溃疡面积的影响和组织病理学改变,采用免疫组织化学法检测创面组织中表皮生长因子(EGF)和碱性成纤维细胞生长因子(bFGF)表达。结果皮粘散可明显减少慢性皮肤溃疡大鼠的溃疡面积,同时也能上调创面组织中EGF和bFGF的表达,此外,组织病理学结果表明,皮粘散也可促进肉芽组织、纤维胶原及新生血管的生长,加速溃疡创面愈合。结论皮粘散对慢性皮肤溃疡有较好的治疗作用,其作用机制与上调EGF及bFGF的表达有关。
Objective To study the clinical effect of topical skin-sticking powder on the treatment of chronic skin ulcers and its mechanism. Methods Rat model of chronic dermal ulcer was established by trauma combined with glacial acetic acid. The effect of epididymitis on ulcer area and histopathological changes were observed. Epidermal growth factor (EGF) and basic fibroblasts Growth factor (bFGF) expression. Results Piyaosan can significantly reduce the ulcer area in rats with chronic skin ulcers, but also upregulate the expression of EGF and bFGF in wound tissues. In addition, histopathological results show that Piyaosan can also promote granulation tissue, fibrillar collagen and neonatal Blood vessel growth accelerates ulcer wound healing. Conclusion Pi Nian San has a good therapeutic effect on chronic skin ulcer and its mechanism is related to the up-regulation of the expression of EGF and bFGF.