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目的:分析HPLC法测定醋酸泼尼松片含量3种不同计算方法的不确定度。方法:建立HPLC法测定醋酸泼尼松片含量的不确定度分析方法。结果:通过对实验过程中各种不确定度因素的分析,确定不确定度分量,合成不确定度。比较3种方法的不确定度大小。结论:进样体积梯度标准曲线法与外标一点法的不确定度值非常接近,均略小于经典标准曲线法。
OBJECTIVE: To analyze the uncertainty of three different calculation methods for the determination of prednisone acetate tablets by HPLC. Methods: To establish an HPLC method for the determination of prednisone acetate tablets uncertainty analysis. Results: Through the analysis of various uncertainty factors during the experiment, the components of uncertainty and the uncertainty of synthesis were determined. Comparison of three methods of uncertainty size. Conclusion: The uncertainty of injection volume gradient standard curve method and external standard one-point method are very close, both slightly smaller than the classical standard curve method.