在全身脓毒症时,器官功能衰竭常伴有神经功能的明显损害。虽然过去曾推想脑低灌注量、缺氧或进行性水肿是致病因素,但其发病机理仍不清楚。脓毒症病人维持其稳定的血流动力学和充分的氧合作用,仍可出现精神错乱、木僵或昏迷。近期证实脑是损伤后许多炎症介质的发源地,这些介质,包括白二烯对脑血管功能有显著的作用。内毒素可刺激细胞膜释放花生四烯酸,涉及白三烯的合成。有认为内毒素血症引起的神经功能失常多伴有颅内压增高,后者可导致脑血管通透性或血管动力改变。作者进行猪实验,共 In systemic sepsis, organ failure is often accompanied by significant impairment of neurological function. Although it has been hypothesized in the past that cerebral hypoperfusion, hypoxia or progressive edema are risk factors, its pathogenesis remains unclear. Sepsis patients to maintain their stable hemodynamics and adequate oxygenation, confusion, stupor or coma can still occur. It has recently been demonstrated that the brain is the birthplace of many inflammatory mediators after injury, and these mediators, including leukotrienes, have a significant effect on cerebrovascular function. Endotoxin can stimulate the release of arachidonic acid membrane, involving the synthesis of leukotrienes. It is thought that endotoxemia caused by neurological dysfunction with increased intracranial pressure, the latter can lead to cerebral vascular permeability or vascular motor changes. The author conducted a pig experiment