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目的探讨原发性肾病综合征对儿童生长发育的影响。方法选取2010年1月至2012年6月间我院收治并有随访的原发性肾病综合征的患儿30例作为观察组,对其予以糖皮质激素治疗;选正常健康体检的儿童30例作为对照组。对观察组正规激素治疗5个月后,对两组儿童的骨代谢水平(BGP、BALP、PTH和血清钙水平)及甲状腺功能(血清TT3、TT4、TSH、FT3、FT4、rT3)进行检测。结果观察组的活动期及缓解期的骨代谢指标与对照组比较(P<0.01),具有统计学意义;观察组甲状腺功能指标与对照组比较(P<0.01),具有统计学意义。结论应用激素治疗肾病综合征对患儿的生长发育有一定的影响。
Objective To investigate the effect of primary nephrotic syndrome on children’s growth and development. Methods Thirty children with primary nephrotic syndrome admitted to our hospital from January 2010 to June 2012 were selected as the observation group and treated with glucocorticoid. 30 normal children As a control group. Five months after the regular hormonal treatment in the observation group, bone metabolism (BGP, BALP, PTH and serum calcium levels) and thyroid function (serum TT3, TT4, TSH, FT3, FT4, rT3) were measured in both groups. Results Compared with the control group, the activity of the observation group and the bone metabolism index of the remission period were statistically significant (P <0.01). The thyroid function indexes of the observation group were statistically significant compared with the control group (P <0.01). Conclusion Hormone treatment of nephrotic syndrome has a certain impact on children’s growth and development.