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在用低压舱模拟连续低压缺氧不同时间的大鼠模型上,观察分析了肺腺泡内动脉结构重建变化与肺循环血流动力学变化的关系。结果表明:缺氧早期(24h后),肺腺泡内动脉即有明显肌化(肌性动脉段增多,非肌性动脉段减少)。随缺氧时间延长,肺腺泡内动脉肌化与肺动脉压增高及右心室代偿性肥厚密切相关。构成肺腺泡内动脉的三种血管段随缺氧时间延长有不同变化趋势,反映出缺氧早期肌性动脉段增多主要经原有部分肌性动脉段转变为肌性动脉段的短捷途径;以后非肌性动脉段经部分肌性动脉段转变为肌性动脉段逐渐成为主要途径。
The relationship between pulmonary alveolar structural remodeling and pulmonary circulation hemodynamics was observed and analyzed in a rat model of continuous hypobaric hypoxia simulated by low-pressure cabin. The results showed that in the early hypoxia (24h), the pulmonary acinar artery was significantly muscular (muscular artery segment increased, non-muscular artery segment decreased). With the extension of hypoxia, the pulmonary acinar artery arterialization and pulmonary hypertension and right ventricular compensatory hypertrophy are closely related. The three vascular segments that constitute the pulmonary acinar artery with different hypoxia time trends have different trends, reflecting the early hypoxia increased mainly by the arterial segment of the original part of the muscular artery segment into a muscular artery segment of the shortcut route ; After non-muscular artery segment by some muscular artery segment into muscle artery segment gradually become the main way.