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替诺福韦具有抗逆转录病毒作用,可以用于治疗年龄18岁以上的HIV-1感染。替诺福韦于2003年3月18日在加拿大被批准使用,2004年3月15日上市。已有报道发现临床使用替诺福韦会出现肾毒性,包括肾功能衰竭、肾功能不全、血肌酐水平升高、低磷酸盐血症及Fanconi综合征等,这些在产品专?
Tenofovir has an antiretroviral effect and can be used to treat HIV-1 infections in people over 18 years of age. Tenofovir was approved for use in Canada on March 18, 2003 and marched on March 15, 2004. It has been reported that nephrotoxicity is present in clinical use of tenofovir, including renal failure, renal insufficiency, elevated serum creatinine, hypophosphatemia and Fanconi syndrome,