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目的:评价增效安神止颤2号方(ZAZ2)对帕金森病PD运动与非运动症状的疗效。方法:102名帕金森病患者随机、双盲分为ZAZ2组(n=65)与安慰剂组(n=37)。在服药前、服药1周以及服药13周后,分别使用帕金森病统一评分量表(UPDRS)积分、帕金森病次要症状量表以及解析加速度记录仪对两组患者的疗效进行评估和比较。结果:与安慰剂组比较,ZAZ2组UPDRS Part IV积分、非运动症状量表积分以及夜间的平均活动量得到了明显改善,而且其体现身体内在活动能力的幂型自相关指数α也有改善。结论:ZAZ2能够改善PD患者的运动与非运动症状,使患者获益;优化混乱碎片分析方法可作为评估帕金森病临床疗效的敏感、有效手段。
OBJECTIVE: To evaluate the efficacy of Zaz2 on PD motility and non-motor symptoms of Parkinson’s disease. METHODS: A total of 102 Parkinson’s disease patients were randomized to double-blind treatment with ZAZ2 (n = 65) and placebo (n = 37). One week before taking medicine, one week after taking medicine and 13 weeks after taking medicine, we used UPDRS score, secondary symptom scale of Parkinson’s disease and analytic acceleration recorder respectively to evaluate and compare the curative effect of the two groups . Results: Compared with placebo group, UPDRS Part IV score, scores of non-motor symptom scale and average activity at night in ZAZ2 group were significantly improved, and power-type autocorrelation index α, which reflects the intrinsic activity of the body, also improved. Conclusions: ZAZ2 can improve the motor and non-motor symptoms of patients with PD and benefit the patients. Optimizing the method of chaos fragmentation can be used as a sensitive and effective method to evaluate the clinical efficacy of Parkinson’s disease.