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目的 探讨亚低温治疗对急性脑梗死患者血胃泌素(gastrin,GAS)变化及临床意义。方法 动态检测1998-10~2002-06云南省第二人民医院ICU科住院的60例急性脑梗死患者亚低温治疗及常规治疗前、第3天、第7天血GAS的变化规律、消化道出血的发生率及神经功能缺损评分。结果 亚低温治疗较常规治疗能明显降低患者血GAS质量浓度(P<0 .01 )、减少急性胃黏膜病变的发生率(P<0 .05 ),降低神经功能缺损评分(P<0. 01)。结论 急性脑梗死患者存在GAS分泌异常,亚低温治疗能明显降低急性脑梗死患者血GAS质量浓度、减少急性胃黏膜病变的发生率,改善脑梗死患者的预后。
Objective To investigate the changes of blood gastrin (GAS) in patients with acute cerebral infarction after mild hypothermia and its clinical significance. Methods The changes of blood GAS in 60 patients with acute cerebral infarction admitted to ICU Department of Second People’s Hospital of Yunnan Province during 1998-10 ~ 2002-06 and the changes of blood GAS before, 3 and 7 days after routine therapy were detected. The gastrointestinal bleeding The incidence and neurological deficit score. Results Compared with conventional treatment, mild hypothermia could significantly reduce the blood concentration of GAS (P0.01), reduce the incidence of acute gastric mucosal lesions (P0.05) and reduce the neurological deficit score (P0.01 ). Conclusions There is abnormal secretion of GAS in patients with acute cerebral infarction. Mild hypothermia treatment can significantly reduce blood GAS concentration in acute cerebral infarction patients, reduce the incidence of acute gastric mucosal lesions and improve the prognosis of patients with cerebral infarction.