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目的分析手足口病儿童病例的肠道病毒7l型(EV71)感染状况。方法采集手足口病(HFMD)病例的血样,通过ELISA间接法检测EV7lIgG和IgM抗体并分析年龄、性别分布情况。结果收集到1379例HFMD儿童病例的血样和资料,年龄为2月~13周岁,平均EV7llgG抗体阳性率为28.72%,无性别差异,平均lgM抗体阳性率为5.49%;EV71IgG阳性率随着年龄增长而呈升高趋势。EV71IgG抗体阳性率最高的年龄组为5岁组,阳性率超过50%;0~1岁年龄组的血清阳性率最低,不超过20%。结论 5岁以下低年龄儿童是肠道病毒71型的易感人群,结果可为HFMD防治提供参考依据。
Objective To analyze the infection status of enterovirus 71 (EV71) in children with HFMD. Methods Blood samples of hand, foot and mouth disease (HFMD) were collected. The EV7I IgG and IgM antibodies were detected by ELISA indirect method and analyzed for age and gender distribution. Results The blood samples and data of 1379 children with HFMD were collected. The mean age was from 2 months to 13 years. The average positive rate of EV71gG antibody was 28.72%. There was no gender difference. The positive rate of lgM antibody was 5.49%. The positive rate of EV71 IgG was increasing with age But showed an upward trend. The highest positive rate of EV71 IgG was in the 5-year-old group, with a positive rate of over 50%. The lowest seroprevalence in the 0-1-year-old group was less than 20%. Conclusions Children under 5 years of age are susceptible to enterovirus 71 and the results may provide a reference for the prevention and treatment of HFMD.