1964年Bain等首次报道了两个遗传上无亲缘关系的人体淋巴细胞在体外一起培养能相互刺激引起淋巴细胞的转化反应,而同卵孪生个体淋巴细胞的混合培养却不能发生这一效应。鉴于科学工作者们对这一现象的重视,在人体,小鼠和大鼠等实验动物中开展了深入的 In 1964, for the first time, Bain et al. Reported that two genetically unrelated human lymphocytes cultured together in vitro could mutually stimulate the transformation reaction of lymphocytes, but this effect could not occur in the mixed cultivation of the same twin twin lymphocytes. As scientists attach importance to this phenomenon, they have conducted in-depth studies in experimental animals such as human beings, mice and rats