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干扰素最初是作为抗病毒物质被发现的,后来才知道它有良好的抗肿瘤作用。长期以来,由于干扰索所具有的种族特异性,限制了它的临床应用。近几年来,随着组织培养技术的发展和遗传工程技术的开发,干扰素的批量生产已成为可能,其临床应用也引超人们日益密切的关注。用于临床的干扰素分3型。α型和β型干扰素有不同的抗原性,但其生物学性质类似,而γ型干扰素具有比α型和β型强10倍到数百倍的抑制免疫、抑制细胞生长的活性,因而具有更强的抗肿瘤作用。另外,若将3型干扰素并用,其抗病毒和肿瘤作用比单独用3型中的任何一型都强。
Interferon was originally found as an anti-viral substance, and later learned that it has a good antitumor effect. For a long time, its clinical application has been limited due to its racial specificity. In recent years, with the development of tissue culture technology and the development of genetic engineering technology, the mass production of interferon has become possible, and its clinical application has drawn more and more attention. Interferon for clinical use divided into 3 types. Alpha and beta interferons have different antigenicities, but their biological properties are similar, whereas gamma interferon has 10 to hundreds-fold more potent immunomodulatory and cytostatic activity than alpha and beta, thus Has a stronger anti-tumor effect. In addition, if type 3 interferon is used, its anti-viral and tumor effects are stronger than any of type 3 alone.