本文应用放射受体分析法测定了一组Huntington舞蹈病患者培养的皮肤成纤维细胞中γ氨基丁酸含量。结果显示本病患者细胞中γ氨基丁酸含量的群体分布与对照组存在着显著差异:前者≤45pmol/μg蛋白的分布比例为75.00%。而后者仅为14.29%(u=2.15>1.96,P<0.05);因此,培养的皮肤成纤维细胞可望成为进一步探讨疾病发生机理的细胞模型;而细胞中γ氨基丁酸含量的改变也可望成为该病早期诊断指标之一。 In this paper, γ-aminobutyric acid in skin fibroblasts from a group of patients with Huntington’s disease was measured by radioimmunoassay. The results showed that there was a significant difference in the distribution of γ-aminobutyric acid in the cells of the patients with the control group: the former ≤45pmol / μg protein distribution ratio was 75.00%. While the latter was only 14.29% (u = 2.15> 1.96, P <0.05). Therefore, the cultured skin fibroblasts are expected to be the cellular model to further explore the pathogenesis of the disease; and the changes of γ-aminobutyric acid content in the cells may also be Hope to become an early diagnosis of the disease one of the indicators.