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目的:检测蛋白质磷酸酶2A(PP2A)的癌性抑制因子(CIP2A)在基底细胞样乳腺癌(BLBC)中的表达,分析CIP2A与BLBC临床病理特征的关系。方法:采用免疫组化方法检测43例BLBC、57例non-BLBC和20例癌旁正常乳腺组织中CIP2A蛋白的表达。结果:免疫组化检测结果显示,BLBC及non-BLBC中CIP2A的表达明显高于癌旁正常乳腺组织,差异有统计学意义,P<0.05;CIP2A蛋白的表达和患者年龄及肿瘤大小无关,与BLBC淋巴结转移及临床分期相关,P<0.05。结论:BLBC组织高表达CIP2A,CIP2A可能与BLBC的发生、发展密切相关。
Objective: To detect the expression of CIP2A in basal-like breast cancer (BLBC) and to analyze the relationship between CIP2A and clinicopathological features of BLBC. Methods: Immunohistochemistry was used to detect the expression of CIP2A protein in 43 cases of BLBC, 57 cases of non-BLBC and 20 cases of normal breast tissues. Results: The results of immunohistochemistry showed that the expression of CIP2A in BLBC and non-BLBC was significantly higher than that in adjacent normal breast tissues (P <0.05). The expression of CIP2A protein was not related to the age of patients and tumor size, BLBC lymph node metastasis and clinical stage, P <0.05. Conclusion: High expression of CIP2A and CIP2A in BLBC may be closely related to the occurrence and development of BLBC.