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Filzgerald等曾通过静脉多次注射高浓度(10~3)的梅毒螺旋体(TP)于孕兔,证明TP能先天传播,在其胚胎组织中可检出TP,新生病兔在产后1～2天内死亡。但是,此家兔的实验模型不能排除母兔在传播TP于胎盘之前已感染梅毒以及在静脉接种时TP通过胎盘直接使胎兔受染的可能。本文报道用叙利亚地鼠成功地建立了先天性梅毒实验模型。对无经产史的10～12周龄雌性叙利亚地鼠(LSH/SsLak近交系)腹股沟皮内接种10~5TP 0.1ml或腹腔接种10~5或10~6TP地方性亚种(BosniaA株),以未接种及腹腔接种经56℃1h灭活的TP于雌地鼠作对照。从接
Filzgerald and other intravenous injection of high concentrations (10 ~ 3) of Treponema pallidum (TP) in pregnant rabbits, proves that TP can be transmitted innately, in its embryo tissue can detect TP, new born rabbits within 1 to 2 days postpartum death. However, the experimental model of this rabbit can not exclude the possibility that female rabbits have been infected with syphilis before transmitting TP to the placenta and that TP directly infects the fetus through the placenta during intravenous inoculation. This article reports the successful establishment of Syrian hamster congenital syphilis experimental model. Inoculation of 10 ~ 5TP 0.1ml or intraperitoneal inoculation of 10 ~ 5 or 10 ~ 6TP endemic subspecies (Bosnia A strain) into the groin of 10 ~ 12-week-old female Syrian hamsters (LSH / SsLak inbred) , Uninoculated and intraperitoneal inoculated with 56 ℃ 1h inactivated TP in female rats as a control. From the pick