本文报道了以氰基乙酸钠、异丙醇为原料,在酸性催化剂存在下一步法合成丙二酸二异丙酯,用H~1 NMR法测定丙二酸二异丙酯混合物各组分的含量。目前国内常采用容量法测定丙二酸二异丙酯混合物中丙二酸二异丙酯的含量,这是将上述混合物碱性水解后,用酸滴定过量碱求出丙二酸二异丙酯含量的。笔者认为容量法测定误差大,因为氰基乙酸钠在反 In this paper, sodium cyanoacetate and isopropanol were used as raw materials to synthesize diisopropylmalonate in one step in the presence of acidic catalyst. The content of each component in the mixture of diisopropylmalonate content. At present, the volumetric method is often used to determine the content of diisopropylmalonate in the mixture of diisopropylmalonate, which is obtained by alkaline hydrolysis of the above mixture and titration of excess base with acid to obtain diisopropylmalonate Content I believe that the determination of volume error, because sodium cyanoacetate in the anti