Expressions of Beta-Catenin,SUFU and VEGFR-2 Proteins in Medulloblastoma

来源 :Chinese Journal of Cancer Research | 被引量 : 0次 | 上传用户:hbl7623308
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Objective:to investigate the expressions of beta-catenin,SUFU and VEGFR-2 proteins in medulloblastoma.Methods:Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin,SUFU and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues.Results:the abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue.While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues.A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma.Conclusion:Beta-catenin,VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma. Objective: to investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma. Methods: Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in 33 cases of Results: the abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. Whilst the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues. A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma. Confusion: Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma.
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