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目的 探讨表皮生长因子 (h EGF)在增生性肾小球肾炎 (PGN)发病中的作用 .方法 采用放射免疫分析法检测2 4例 PGN、12例非 PGN患者及 13例正常人血清、尿液和肾活检组织 h EGF含量 .结果 PGN组肾组织、尿 h EGF含量显著高于非 PGN组 (0 .6 3± 0 .18vs 0 .5 9± 0 .15 ,2 75± 5 1vs6 4± 19,P<0 .0 1)和正常对照组 (0 .6 3± 0 .18vs0 .5 4± 0 .14 ,2 75± 5 1vs5 4± 18,P<0 .0 1) ,PGN组血清 h EGF较非PGN和正常对照组均无显著差异 :肾组织 h EGF含量愈高 ,肾小球病理改变程度愈重 (r=0 .6 5 1,P<0 .0 1) ;尿 h EGF含量与肾组织 h EGF含量正相关 (r=0 .80 6 ,P<0 .0 0 1) .结论 h EGF可能与 PGN发病机制有关 ,尿 h EGF含量测定可反映肾组织局部 h EGF含量变化 .
Objective To investigate the role of epidermal growth factor (h EGF) in the pathogenesis of proliferative glomerulonephritis (PGN) .Methods Radioimmunoassay was used to detect the serum and urine of 24 PGN patients, 12 non-PGN patients and 13 normal controls And h-EGF in renal biopsy tissues.Results The content of EGF in kidney and urine of PGN group was significantly higher than that of non-PGN group (0.63 ± 0.18 vs 0.59 ± 0.15, 2 75 ± 5 1 vs 64 ± 19 , P <0.01) and normal control group (0 .6 3 ± 0.18 vs0.54 ± 0.14, 2 75 ± 5 1 vs5 4 ± 18, P <0.01), serum h Compared with non-PGN group and normal control group, there was no significant difference in EGF between the two groups (P <0.01). The higher the content of EGF in renal tissue, the more severe the glomerular pathological changes (r = 0.651, P <0.01) (R = 0.806, P0.01) .Conclusion h EGF may play an important role in the pathogenesis of PGN. The determination of urinary h EGF content may reflect the change of h EGF content in renal tissue.