动脉粥样硬化是一种起源于脂质,尤其是低密度脂蛋白的慢性炎症性及血栓形成性疾病.动脉粥样硬化斑块中含有大量可以诱导炎症反应的免疫细胞,其中以CD4+T细胞亚群中的辅助性T细胞1最多见,此外还包括含量较低的辅助性T细胞2、辅助性T细胞17、调节性T细胞.这些CD4+T细胞通过自分泌或旁分泌方式释放多种细胞因子,并通过作用于炎症细胞调节动脉粥样硬化斑块的发生和发展.鉴于促炎与抗炎反应平衡是决定炎症性疾病进展的主要因素,评估循环系统中细胞因子水平与动脉粥样硬化性疾病的关系已成为研究的热点.现就不同T细胞亚群在动脉粥样硬化发生及发展过程中变化以及其与动脉粥样硬化的关系做一综述.“,”Atherosclerosis has been considered as a chronic inflammatory and thrombosis disease which originates from lipid,especially low density lipoprotein.There are lots of immune cells in the atherosclerotic plaques which can induce inflammatory response.The most common part is Th1 in CD4+T cell subset,and small amount of Th2,Th17 and Treg can also be seen.All these CD4+T cells effect on inflammatory cells and regulate atherosclerosis development and progression through cytokines released by autocrine or paracrine.Due to pro-and anti-inflammatory balance is a major determinant of inflammatory disease progression,many studies have focused on the relationship between cytokine level and atherosclerosis disease in cardiovascular system.This review summarizes the changes of different T cell subsets during atherosclerosis origination and development,and their relationship with atherosclerosis.