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为研究微生物菌种在空间条件下产生的变异，在利用我国发射的返回式卫星上，搭载了适用于突变研究的大肠杆菌菌株ＣＳＨ１０８、Ａ３和Ａ２，使用了三种搭载方式。卫星返回后，测定了菌种的存活及产生的ｌａｃＩ－突变和Ａｒｇ＋回复突变的频率。结果表明：大肠杆菌在空间条件下是可以存活的；经小生物舱搭载的Ａ３菌株产生的ｌａｃＩ－突变体的频率是地面对照的６７倍；铅罐中搭载的ＣＳＨ１０８菌株产生的Ａｒｇ＋的回复突变频率是地面对照的１０倍左右，而且回复体中无义抑制基因的突变频率明显增加。由此可见，空间条件有可能显著地提高微生物中某些基因的突变频率，空间诱变可望成为获得微生物优良菌种的有效途径之一。
In order to study the variation of microbial strains under the space conditions, three types of loading methods were used on the returning satellites launched by our country, Escherichia coli strains CSH108, A3 and A2 which are suitable for mutation research. After the satellite returned, the viability of the species and the frequency of lacI-mutations and Arg + -reverted mutations were determined. The results showed that Escherichia coli could survive under space conditions; the frequency of lacI-mutant produced by the A3 strain carried by the small biological tank was 67 times that of the ground control; and the reverse mutation of Arg + produced by the CSH108 strain carried in the lead tank The frequency is about 10 times that of the ground control, and the frequency of mutation of the nonsense suppressor gene is obviously increased in the recovery body. Thus, space conditions may significantly improve the mutation frequency of some genes in microorganisms, and space mutation is expected to be one of the effective ways to obtain fine strains of microorganisms.