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P-糖蛋白(P-gp)由MDR1基因编码,腺苷三磷酸依赖的药物外向转运蛋白,是介导药物吸收与转运动力学的关键转运体。不少药物通过核因子κB(NF-κB)和孕烷X受体(PXR)信号通路直接影响MDR1基因和P-gp的表达,导致P-gp的功能发生改变,从而影响药物的吸收转运。因此,本文对P-gp介导的药物转运相互作用、药物对P-gp和MDR1基因表达的影响,以及与P-gp/MDR1基因表达相关的NF-κB和PXR信号通路的研究概况进行收集与探讨,以期从基因和蛋白水平上,为研究药物吸收转运特征的变化提供一定依据。
P-glycoprotein (P-gp), encoded by the MDR1 gene, is an adenosine triphosphate-dependent drug efflux transporter that is a key transporter that mediates drug absorption and transport kinetics. Many drugs directly affect the expression of MDR1 gene and P-gp through NF-κB and PXR signaling pathways, which lead to the change of P-gp function and thus the absorption and transport of drugs. Therefore, we collected the P-gp-mediated drug transport interactions, the effect of drugs on the expression of P-gp and MDR1 genes, and the profiles of the NF-κB and PXR signaling pathways involved in P-gp / MDR1 gene expression And explore, in order to provide some evidence from the gene and protein levels, to study changes in the absorption and transport characteristics of drugs.