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为探讨血浆内皮素(ET)在弥漫性甲状腺肿伴甲亢(Graves病)、单纯性甲状腺肿及慢性淋巴细胞性甲状腺炎(桥本氏病)患者中的变化及与甲状腺激素(FT_3FT_4)的关系.使用放射免疫法检测了52例Graves病,47例单纯性甲状腺肿,12例桥本氏病患者ET、FT_3、FT_4水平,并与30例正常人进行比较.结果Graves病及单纯性甲状腺肿患者ET均显著高于正常人.桥本氏病患者ET显著低于正常组.各组的ET与FT_3、FT_4 呈正相关.提示甲状腺疾病有ET的参与.
To investigate the relationship between plasma endothelin (ET) and thyroid hormone (FT_3FT_4) in patients with diffuse goiter with Graves’ disease, simple goiter and chronic lymphocytic thyroiditis (Hashimoto’s disease) The levels of ET, FT_3 and FT_4 in 52 cases of Graves disease, 47 cases of simple goiter and 12 cases of Hashimoto’s disease were detected by radioimmunoassay and compared with 30 normal subjects.Results Graves’ disease and simple goiter ET in patients with Hashimoto’s disease was significantly higher than that in normal people, ET in Hashimoto’s disease patients was significantly lower than that in normal group, ET in each group was positively correlated with FT_3 and FT_4, suggesting the involvement of ET in thyroid disease.