对于呼吸衰竭动物模型应用液体通气已证明能改善气体交换,但用于临床则至今只有3例早产儿因表面活性物质缺乏致婴儿RDS的报道。为了评价部分液体通气对治疗成人及儿童呼吸衰竭的安全性及有效性,作者进行了部分液体通气的临床应用研究。 研究观察了19例严重呼吸衰竭的患者,其中成人10例,儿童4例,足月新生儿5例。呼吸衰竭病因包括肺炎、哮喘、毛细血管渗漏综合征、先天性膈疝、肺动脉 Liquid ventilation has been shown to improve gas exchange in animal models of respiratory failure, but only 3 cases of premature infants have been clinically reported to have RDS due to lack of surfactant. In order to evaluate the safety and effectiveness of some liquid ventilation in the treatment of respiratory failure in adults and children, the author conducted a clinical study of partial liquid ventilation. Nineteen patients with severe respiratory failure were observed, including 10 adults, 4 children and 5 full-term newborns. Causes of respiratory failure include pneumonia, asthma, capillary leak syndrome, congenital diaphragmatic hernia, pulmonary arteries