论文部分内容阅读
应用免疫组化方法检测 3 8例肝外胆管癌、1 4例非肿瘤胆管组织 (8例胆总管囊肿、6例正常胆管 )中 TGF- βR (转化生长因子 - βII型受体 )的表达情况 ,探讨 TGF- βR 在肝外胆管癌中的表达及意义。结果 :1 TGF- βRII在肝外胆管癌中的阳性表达率明显降低 :TGF- βRII阳性率为 2 8.95 % (1 1 /3 8) ,非肿瘤对照组为 92 .86 % (1 3 /1 4) ;2 TGF-βRII的阳性表达率在转移组中明显低于未转移组 (1 8.75 %、1 4.2 9%、0对 5 8.3 3 % )。提示TGF- βRII在肝外胆管癌的发生中起着重要作用 ,对其进行检测可作为肝外胆管癌的辅助诊断参考指标之一 ,并可为肝外胆管癌自然病程的判断和治疗方法的选择提供部分依据。
Immunohistochemistry was used to detect the expression of TGF-βR (transforming growth factor-β type II receptor) in 38 cases of extrahepatic cholangiocarcinoma and 14 non-tumor bile duct tissues (8 cases of common bile duct cyst and 6 cases of normal bile duct). To investigate the expression and significance of TGF-βR in extrahepatic cholangiocarcinoma. RESULTS: 1 The positive expression rate of TGF-βRII in extrahepatic cholangiocarcinoma was significantly lower: the positive rate of TGF-βRII was 28.95% (1 1 /3 8), and the non-tumor control group was 92.86% (1 3 /1 The positive rate of TGF-βRII in the metastatic group was significantly lower than that in the non-metastatic group (18.75%, 14.2%, 0 vs. 58.3%). It is suggested that TGF-βRII plays an important role in the occurrence of extrahepatic cholangiocarcinoma. Detection of TGF-βRII may be used as an auxiliary diagnostic index for extrahepatic cholangiocarcinoma, and it can be used to determine the natural course of extrahepatic bile duct cancer and its treatment method. Choose to provide partial basis.