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红细胞体积的变异可通过周围血片检查,常规地用以判断红细胞大小不均的程度。但形态上的变异可能与体积上的变异相混淆,妨碍分析。作者用红细胞体积分布矩形图测定红细胞大小不均,即测定红细胞体积的变异系数(CV),以证实缺铁性贫血和轻型地中海贫血之间有明显差异。85例患者,平均红细胞容积(MCV)均小于70毫微微升。其中53例血清铁饱和度<10%,用铁后MCV恢复正常,血红蛋白增加,血红蛋白电泳正常,从而诊断缺铁性贫血。这些患者的血红蛋白是4.6%～13.7
Variation of the volume of red blood cells can be checked by the peripheral blood films, routinely used to determine the extent of uneven red blood cell size. However, the morphological variation may be confused with the volume variation, hindering the analysis. The authors used a red blood cell volume distribution histogram to measure red blood cell heterogeneity, ie, the coefficient of variation (CV) of the erythrocyte volume, to confirm that there was a significant difference between iron deficiency anemia and thalassemia minor. 85 patients, the average volume of red blood cells (MCV) were less than 70 femtoliters. Among 53 cases, serum iron saturation was less than 10%, MCV returned to normal after using iron, hemoglobin increased, hemoglobin electrophoresis was normal, and iron deficiency anemia was diagnosed. The hemoglobin of these patients is 4.6% ~ 13.7