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目的探讨老年充血性心力衰竭治疗后N末端脑钠尿肽前体(NT-pro BNP)不同水平患者预后情况。方法 50例老年充血性心力衰竭患者作为研究对象,测定不同心功能患者治疗前后NT-pro BNP水平,观察患者的预后情况。结果治疗后,心功能Ⅱ级患者NT-pro BNP水平为(98.2±34.5)pg/ml,心功能Ⅲ级患者NT-pro BNP水平为(312.2±82.3)pg/ml,心功能Ⅳ级患者NT-pro BNP水平为(834.4±309)pg/ml。出院时,心功能Ⅱ级患者NT-pro BNP水平为(20.2±10.5)pg/ml,心功能Ⅲ级患者NT-pro BNP水平为(68.3±43.7)pg/ml,心功能Ⅳ级患者NT-pro BNP水平为(122.2±30.5)pg/ml。心功能Ⅳ级患者的NTpro BNP水平明显高于心功能Ⅱ、Ⅲ级患者,不同级别患者的NT-pro BNP水平比较差异具有统计学意义(P<0.05)。结论 NT-pro BNP水平可以有效的预测老年充血性心力衰竭,对患者的预后具有重要的临床价值,值得临床应用与推广。
Objective To investigate the prognosis of patients with different levels of N-terminal pro-brain natriuretic peptide (NT-pro BNP) after treatment of senile congestive heart failure. Methods Fifty elderly patients with congestive heart failure were enrolled in this study. The levels of NT-pro BNP in patients with different cardiac functions before and after treatment were measured and the prognosis of the patients was observed. Results After treatment, the level of NT-pro BNP was (98.2 ± 34.5) pg / ml in patients with grade Ⅱ cardiac function, NT-pro BNP was (312.2 ± 82.3) pg / ml in patients with grade Ⅲ cardiac function, NT -pro BNP level was (834.4 ± 309) pg / ml. At discharge, NT-pro BNP level was (20.2 ± 10.5) pg / ml in patients with cardiac function gradeⅡ, NT-pro BNP level was (68.3 ± 43.7) pg / ml in patients with cardiac function gradeⅢand NT- Pro BNP levels were (122.2 ± 30.5) pg / ml. The levels of NTpro BNP in patients with grade IV heart function were significantly higher than those in patients with gradeⅡand Ⅲ cardiac function. There was significant difference in the level of NT-pro BNP in patients with different grades (P <0.05). Conclusions The level of NT-pro BNP can effectively predict senile congestive heart failure and has important clinical value for the prognosis of patients. It is worthy of clinical application and promotion.