【摘 要】
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Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro;thus,they have a great potential in the treatment of hemopathies.Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR).However,few
【机 构】
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Department of Hematology,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 2
论文部分内容阅读
Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro;thus,they have a great potential in the treatment of hemopathies.Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR).However,few studies have reported on the regulation of proliferative behaviors and metabolism by AHR in BMMSCs.In the present study,we found that activating AHR reduced the proliferation of BMMSCs and enhanced their mitochondrial function,whereas inhibiting AHR exerted the opposite effects.This study may pro-vide the basis for further unveiling the molecular mechanisms and therapeutic potential of AHR in BMMSCs.
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