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类风湿性中性粒细胞性皮炎(RND)是类风湿性关节炎(RA)患者中罕见的一种皮肤表现。自1978年Ackerman首次描述此病以来,文献上仅报道过8例。具有这种关节外表现的RA患者,通常血清类风湿因子(RF)阳性且病情严重,但皮损却无自觉症状。以往报道的RND常见于中年女性,其皮疹可以是荨麻疹样或呈环状,亦可表现为红斑、皮下丘疹、斑块和结节,主要分布于躯干、肩颈以及四肢。单个损害持续1～3周,能自行缓解或随RA的好转而自愈,通常不留瘢痕,但可有短暂的色素沉着。
Rheumatoid neutrophilic dermatitis (RND) is a rare skin manifestation in patients with rheumatoid arthritis (RA). Since Ackerman first described the disease in 1978, only eight cases have been reported in the literature. RA patients with this extra-articular appearance usually have a serum-type rheumatoid factor (RF) positive and have a serious condition, but the skin lesions have no symptoms. Previously reported RND is common in middle-aged women, the rash can be urticaria-like or ring-shaped, can also be expressed as erythema, subcutaneous papules, plaques and nodules, mainly in the trunk, neck and limbs. A single injury lasted 1 to 3 weeks, can relieve itself or with the improvement of RA and self-healing, usually without leaving scars, but there may be transient pigmentation.