论文部分内容阅读
通过对中国维吾尔族人群HLA-B等位基因的分布频率的研究,探讨HLA-B等位基因与HIV感染的易感 或抵抗性的相关性。本研究用PCR-SSP的方法对新疆维吾尔族110例无相关的健康对照者(HIV阴性)和128例 HIV阳性感染者进行HLA-B等位基因分型。用POPGEN软件对健康对照者人群进行Hardy-Weinberg平衡检 测,用卡方检验分析HLA-B等位基因在健康对照者和HIV阳性感染者频率分布的差异。在HIV-1阳性感染者 中,B*4901等位基因频率显著性增加(B*4901:P=0．02．OR=3．06,95%CI=1．16～8．10)。而在健埭对照者 中,B*40等位基因顿率增加具有统计意义(B*40:P=0．02．OR=0．39．95％CI=0．07～0．92)。由此可见,B* 4901等位基因可能与HIV-1感染的易感性有关,而B*40等位基因可能与与HIV-1感染的抵抗性有关。
By studying the distribution frequency of HLA-B alleles in Chinese Uyghur population, the relationship between HLA-B alleles and susceptibility or resistance to HIV infection was explored. In this study, HLA-B alleles were genotyped by PCR-SSP in 110 unrelated healthy controls (HIV-negative) and 128 HIV-positive patients in Xinjiang Uigur. Hardy-Weinberg equilibrium was detected by POPGEN software in healthy controls, and the frequency distribution of HLA-B alleles in healthy controls and HIV-positive patients was analyzed by chi-square test. The frequency of B * 4901 allele was significantly increased in HIV-1-positive patients (B * 4901: P = 0.02.OR = 3.06, 95% CI = 1.16-8.10). In healthy controls, the B * 40 allele frequency increased statistically significant (B * 40: P = 0.02.OR = 0.39.95% CI = 0.07 ~ 0.92). Thus, the B * 4901 allele may be related to the susceptibility of HIV-1 infection, while the B * 40 allele may be related to the resistance to HIV-1 infection.