急性重型、亚急性重型及慢性重型病毒性肝炎均可于病程后期发生肾功能衰竭。过去临床上习惯于用“肝肾综合征”来概括这一临床表现。以后“肝肾综合征”一词被扩大范围用以描述各种肝与肾两个脏器同时受累所出现的征丛,如败血症、钩端螺旋体病、全身性红斑性狼疮、妊娠中毒症等。鉴于上述情况,1973年Conn提出:凡肝脏与肾脏同时受到某种疾病过程的影响,而肝病的发生并不先于肾病者应称为“假性肝肾综合征”,以便与慢性肝病晚期,最终伴发肾功能衰竭的特定综合征相区别。1962年Vesin发现肝硬化发生肾功能衰竭时,患者的肾脏的病理改变与临床表现不相符合,因而提出“功能性肾衰竭”一词,这种提法以后陆续 Acute severe, subacute severe and chronic severe viral hepatitis can occur in the late course of renal failure. In the past, it was customary to summarize this clinical manifestation with “hepatorenal syndrome”. After the “hepatorenal syndrome” was extended to describe the scope of a variety of liver and kidney organs involved in the same syndrome, such as sepsis, leptospirosis, systemic lupus erythematosus, gestosis, etc. . In view of the above situation, in 1973, Conn proposed: where the liver and kidneys are affected by a certain disease process, and liver disease does not occur before the kidney disease should be referred to as “pseudo-liver syndrome” so that with advanced liver disease, The specific syndrome that eventually accompanies renal failure differs. In 1962, when Vesin found that renal failure occurred in patients with cirrhosis, the pathological changes in the kidneys of the patients were not in accordance with the clinical manifestations. Therefore, the term “functional renal failure” was put forward one after another