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本文报导了在弱酸性条件下,用叠氮基直接取代醌环上一个氢原子合成叠氮泛醌类化合物的新方法。合成了五种叠氮泛醌类化合物:2—叠氮基—3—甲氧基—6—甲基—5—(牛龙)牛儿—基—1,4—苯醌,3—叠氮基—2—甲氧基—6—甲基—5—(牛龙)牛儿基—1,4—苯醌,6—叠氮基—2,3—二甲氧基—5—(牛龙)牛儿基—1,4—苯醌,2—叠氮基—3—甲基—6—甲氧基—5—(牛龙)牛儿基—1,4苯醌和3—叠氮基—2—甲基—6—甲氧基—5—(牛龙)牛儿基—1,4苯醌.这些叠氮泛醌的结构已由核磁共振谱,紫外光谱,红外光谱及质谱数据所证明。所有这些化合物在线粒体呼吸链的电子迁移反应中都具有部分生理活性.此外,对醌环进行叠氮化反应的机理作了初步的探讨.同时还简要描述了叠氮泛醌化合物以紫外光照射下的光化学反应性质.
This paper reports a new method for the synthesis of azido ubiquinones from a hydrogen atom on the quinone ring by azido directly under weakly acidic conditions. Five azido ubiquinones were synthesized: 2-azido-3-methoxy-6-methyl-5- Methoxy-6-methyl-5- (oxetan) -budiol-1,4-benzoquinone, 6-azido-2,3-dimethoxy-5- ) Oxazino-1,4-benzoquinone, 2-azido-3-methyl-6-methoxy-5- Methyl-6-methoxy-5- (oxetan) -1,4-benzoquinone.The structures of these azido-ubiquinones have been characterized by 1H-NMR, UV, IR and MS data prove. All of these compounds have some physiological activities in the electron transfer reaction of the mitochondrial respiratory chain.In addition, the mechanism of azidation of quinone ring was preliminarily discussed.At the same time, a brief description of the azido-ubiquinone compounds irradiated by ultraviolet light Under the photochemical reaction properties.