雷诺嗪是一个新型的心血管治疗药物,其作用机制同其抑制心肌细胞动作电位中的晚期钠离子流有关。雷诺嗪能有效抑制晚钠内流,进而缓解心肌缺血,改善心脏舒缩功能和遏止相关心律失常的发生,临床研究表明雷诺嗪可提高运动耐量,减少心绞痛发作次数,减少硝酸甘油用量。雷诺嗪尚有抗心律失常和改善心脏收缩及舒张功能的作用。 Ranolazine is a novel cardiovascular drug whose mechanism of action is related to its ability to inhibit late sodium currents in cardiomyocyte action potentials. Ranolazine can effectively inhibit the influx of sodium late, and then relieve myocardial ischemia, improve cardiac systolic and diastolic function and to prevent the occurrence of arrhythmia. Clinical studies show that ranolazine can improve exercise tolerance, reduce the number of angina attacks, reduce the amount of nitroglycerin. Ranolazine still anti-arrhythmia and improve cardiac systolic and diastolic function.