论文部分内容阅读
本文概述了医院药房中三硝酸甘油酯的合成、含量测定以及静脉注射液的制备。三硝酸甘油酯主要用于心绞痛的治疗,以0.05毫克/分速度静脉注射时所导致的降压作用比舌下给药强10倍。将其静脉注射液用于冠状动脉手术患者以降低血压和增加周围循环,偶而亦用于“进行性”心绞痛患者,经四年临床试用,结果证明安全有效。制备:甘油、硝酸和硫酸按(20:47:71)之比进
This article summarizes the synthesis of glyceryl trinitrate in hospital pharmacies, the determination of its content, and the preparation of intravenous fluids. Trinitrate is mainly used in the treatment of angina pectoris, when the intravenous injection at a rate of 0.05 mg / min results in a 10-fold lower blood pressure-lowering effect than the sublingual administration. Its IV solution for coronary artery surgery in patients with lower blood pressure and increased peripheral circulation, and occasionally also for “progressive” angina patients, after four years of clinical trials, the results proved safe and effective. Preparation: glycerol, nitric acid and sulfuric acid by (20:47:71) into the ratio