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目的:探讨血清前列腺特异性抗原(PSA)浓度变化在慢性前列腺炎发生、发展及疗效评价中的意义。方法:用ELISA法测定60例慢性前列腺炎患者(慢性前列腺炎组)直肠指检前的血清PSA浓度,以正常者30例为对照组,并对比慢性前列腺炎治疗前后患者血清PSA浓度的变化。结果:慢性前列腺炎组和对照组的血清PSA浓度分别为(1.6±0.3)和(0.5±0.2)μg/L,两组间差异有极显著性(t=11.68,P<0.01)。45例慢性前列腺炎治疗有效者,治疗后血清PSA浓度较治疗前明显下降(P<0.01),而15例治疗无效者,血清PSA浓度较治疗前下降不明显(P>0.05)。结论:慢性前列腺炎时血清PSA浓度明显升高,经治疗随着炎症的消失,PSA浓度可逐渐恢复正常,PSA浓度可作为慢性前列腺炎疗效评价的指标之一。
Objective: To investigate the significance of the change of serum prostate specific antigen (PSA) concentration in the occurrence, development and therapeutic effect of chronic prostatitis. Methods: Serum PSA levels of 60 patients with chronic prostatitis (chronic prostatitis) before rectal examination were determined by ELISA. The serum PSA levels of 30 patients with normal prostatitis were compared before and after treatment. Results: Serum PSA concentrations in chronic prostatitis group and control group were (1.6 ± 0.3) and (0.5 ± 0.2) μg / L, respectively. There was significant difference between the two groups (t = 11.68, P <0.01). 45 cases of chronic prostatitis effective treatment, after treatment serum PSA concentration was significantly lower than before treatment (P <0.01), while 15 cases of ineffective treatment, serum PSA concentration decreased compared with before treatment was not significant (P> 0.05). Conclusion: The concentration of serum PSA in patients with chronic prostatitis is significantly higher than that in patients with chronic prostatitis. After the treatment, the concentration of PSA can gradually return to normal with the disappearance of inflammation. PSA concentration can be used as one of the indicators for evaluating the curative effect of chronic prostatitis.