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1Fas和FasL系统Fas属于TNFR/NGFR(肿瘤坏死因子受体/神经生长因子受体)超家族的Ⅰ型跨膜蛋白,胞内区有一段80个氨基酸的序列与细胞的凋亡信号传递有关,称为死亡功能区。Fas蛋白有两种形式:膜结合型(mFas)和可溶型(sFas),主要以膜受体形式存在,也可通过转录水平的不同拼接产生sF
1Fas and FasL Fas belong to the type I transmembrane protein of TNFR / NGFR (tumor necrosis factor receptor / nerve growth factor receptor) superfamily. A sequence of 80 amino acids in the intracellular region is related to the signal transduction of apoptosis. Known as the death function area. There are two forms of Fas protein: membrane-associated (mFas) and soluble (sFas), mainly in the form of membrane receptors, but also spliced by different transcription levels of sF