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目的:利用快速卫生技术评估工具对达托霉素霉素治疗感染性心内膜炎进行有效性、安全性、经济性评估,为医院药物遴选提供参考。方法:通过计算机检索PubMed、the Cochrane Library等英文数据库和中国知网(CNKI)、中国生物医学文献服务系统(SinoMed)、万方数据等中文数据库。2名评价者独立提取数据结果。仅纳入达托霉素治疗感染性心内膜炎的系统评价、Meta分析、卫生技术评估和药物经济学研究,同时采用描述性分析对研究结论进行分类汇总。结果:共纳入3篇文献,1项为系统评价,2项为药物经济学研究。采用达托霉素治疗感染性心内膜炎的有效性和安全性研究结果与对照组(安慰剂、其他阳性对照药单药或联合其他常规用药)比较,差异均无统计学意义,药物经济学研究显示成本效果优于对照组。结论:对达托霉素治疗感染性心内膜炎的评估发现,快速卫生经济技术评估工具可作为一种简洁、快捷、易行的方法,为医院的药物遴选提供参考。
OBJECTIVE: To evaluate the efficacy, safety and economy of daptomycin for the treatment of infective endocarditis by using rapid health assessment tools, which can provide a reference for the selection of hospital drugs. METHODS: Chinese databases such as PubMed, the Cochrane Library and Chinese databases CNKI, SinoMed and Wanfang Data were searched by computer. Two reviewers independently extracted data results. Only included in the systematic evaluation of daptomycin treatment of infective endocarditis, Meta analysis, health technology assessment and pharmacoeconomics, descriptive analysis of the conclusions of the study were summarized. Results: A total of three articles were included, one was systematic review and two were pharmacoeconomic studies. The efficacy and safety of daptomycin in the treatment of infective endocarditis The results of the study compared with the control group (placebo, other positive control drugs alone or in combination with other conventional drugs), the difference was not statistically significant, drug economy Study shows that the cost-effective than the control group. Conclusion: The evaluation of daptomycin in the treatment of infective endocarditis found that rapid economic and economic assessment tools can be used as a simple, quick and easy way to provide reference for the hospital drug selection.