以杨木屑粉为原料,以TiO2-SiO2固体酸为水解催化剂,探讨了固体酸的用量、水解温度、液固比和水解时间对乙酰丙酸得率的影响,采用响应面法建立二次回归模型,并对水解工艺进行了优化。研究结果表明,当液固比为14∶1、固体酸的用量为3.53%、温度为241℃、水解时间为36min时为较优的制备工艺,在该工艺条件下,乙酰丙酸的得率为23.11% The effect of solid acid dosage, hydrolysis temperature, liquid-solid ratio and hydrolysis time on the yield of levulinic acid was explored using poplar wood flour as raw material and TiO2-SiO2 solid acid as hydrolysis catalyst. Response surface methodology was used to establish the second regression Model, and the hydrolysis process has been optimized. The results show that when the ratio of liquid to solid is 14:1, the amount of solid acid is 3.53%, the temperature is 241 ℃ and the hydrolysis time is 36min, the preparation process is the best. Under these conditions, the yield of levulinic acid 23.11%