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目的:探讨结构式家庭疗法联合舍曲林治疗首发青少年强迫症的临床疗效及副反应。方法:符合ICD-10强迫症诊断标准的41例首发青少年强迫症患者,被随机分为研究组(n=21,结构式家庭疗法联合舍曲林治疗)及对照组(n=20,单用舍曲林治疗),观察时间为12周。分别比较治疗4、8、12周后两组Yale-Brown强迫量表、副反应量表(TESS)评分情况。结果:1在治疗的第4、8、12周末,研究组的强迫评分显著低于对照组(P<0.01);2治疗12周后研究组总有效率为81%,对照组总有效率40%,差异具有显著性统计学意义(χ2=7.220,P<0.01);3在治疗第4、8、12周末,两组患者的TESS量表评分,差异不具有统计学意义(P>0.05)。结论:对首发青少年强迫症患者,结构式家庭疗法联合舍曲林治疗能快速、有效地改善强迫症状,且具有不增加药物副反应的特点,依从性好。
Objective: To investigate the clinical efficacy and side effects of structured home therapy combined with sertraline in the treatment of adolescent obsessive-compulsive disorder. Methods: Forty-one patients with obsessive-compulsive disorder (OCD) who met the diagnostic criteria for ICD-10 obsessive compulsive disorder were randomly divided into study group (n = 21, structured home therapy combined with sertraline) and control group (n = 20, Qu Lin treatment), observation time of 12 weeks. The Yale-Brown coercion and TESS scores were compared between the two groups after 4, 8 and 12 weeks of treatment. At the end of the 4th, 8th and 12th week of treatment, the compulsive score of the study group was significantly lower than that of the control group (P <0.01); 2 The total effective rate of the study group was 81% after 12 weeks of treatment, and the total effective rate of the control group was 40 %, The difference was statistically significant (χ2 = 7.220, P <0.01); 3 in the treatment of the 4th, 8th and 12th week, the TESS scale scores of the two groups had no statistical significance (P> 0.05) . CONCLUSIONS: The structured home therapy combined with sertraline can improve obsessive-compulsive symptoms rapidly and effectively in patients with first-episode obsessive-compulsive disorder, and has the characteristics of not increasing side effects of drugs and good compliance.